First Generation of Antioxidant Precursors for Bioisosteric Se-NSAIDs: Design, Synthesis, and In Vitro and In Vivo Anticancer Evaluation

• Main Authors: Sandra Ramos-Inza (Author), Cesar Aliaga (Author), Ignacio Encío (Author), Asif Raza (Author), Arun K. Sharma (Author), Carlos Aydillo (Author), Nuria Martínez-Sáez (Author), Carmen Sanmartín (Author), Daniel Plano (Author)
• Format: Book
• Published: MDPI AG, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The introduction of selenium (Se) into organic scaffolds has been demonstrated to be a promising framework in the field of medicinal chemistry. A novel design of nonsteroidal anti-inflammatory drug (NSAID) derivatives based on a bioisosteric replacement via the incorporation of Se as diacyl diseleni...