RNA Nanotherapeutics for the Amelioration of Astroglial Reactivity

• Main Authors: Jayden A. Smith (Author), Alice Braga (Author), Jeroen Verheyen (Author), Silvia Basilico (Author), Sara Bandiera (Author), Clara Alfaro-Cervello (Author), Luca Peruzzotti-Jametti (Author), Dan Shu (Author), Farzin Haque (Author), Peixuan Guo (Author), Stefano Pluchino (Author)
• Format: Book
• Published: Elsevier, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In response to injuries to the CNS, astrocytes enter a reactive state known as astrogliosis, which is believed to be deleterious in some contexts. Activated astrocytes overexpress intermediate filaments including glial fibrillary acidic protein (GFAP) and vimentin (Vim), resulting in entangled cells...