Clofarabine Has Apoptotic Effect on T47D Breast Cancer Cell Line via P53R2 Gene Expression

• Ngā kaituhi matua: Mohammad Rahmati-Yamchi (Author), Nosratollah Zarghami (Author), Hojjatollah Nozad Charoudeh (Author), Yasin Ahmadi (Author), Behzad Baradaran (Author), Mohammad Khalaj-Kondori (Author), Morteza Milani (Author), Abolfazl Akbarzadeh (Author), Maghsud Shaker (Author), Mohammad Pourhassan-Moghaddam (Author)
• Hōputu: Pukapuka
• I whakaputaina: Tabriz University of Medical Sciences, 2015-11-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Purpose: Clofarabine, a purine nucleoside analogue and inhibitor of Ribonucleotide Reductase (RR), is used for treatment of leukemia. Clofarabine-induced defect in DNA replication, induces p53 and subsequently P53R2 genes as subunit of RR. clofarabine deregulated P53R2 gene expression leading to the...