Intra‐lymph node crosslinking of antigen‐bearing polymers enhances humoral immunity and dendritic cell activation

• Main Authors: Erin M. Euliano (Author), Anushka Agrawal (Author), Marina H. Yu (Author), Tyler P. Graf (Author), Emily M. Henrich (Author), Alyssa A. Kunkel (Author), Chia‐Chien Hsu (Author), Tsvetelina Baryakova (Author), Kevin J. McHugh (Author)
• Format: Book
• Published: Wiley, 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Lymph node (LN)‐resident dendritic cells (DCs) are a promising target for vaccination given their professional antigen‐presenting capabilities and proximity to a high concentration of immune cells. Direct intra‐LN injection has been shown to greatly enhance the immune response to vaccine an...