Prostate cancer cells and exosomes in acidic condition show increased carbonic anhydrase IX expression and activity

• Main Authors: Mariantonia Logozzi (Author), Clemente Capasso (Author), Rossella Di Raimo (Author), Sonia Del Prete (Author), Davide Mizzoni (Author), Mario Falchi (Author), Claudiu T. Supuran (Author), Stefano Fais (Author)
• Format: Book
• Published: Taylor & Francis Group, 2019-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acidity and hypoxia are crucial phenotypes of tumour microenvironment both contributing to the selection of malignant cells under a micro evolutionistic pressure. During the tumour progression, nanovesicles, called exosomes and the metalloenzyme carbonic anhydrase IX (CA IX) affect the tumour growth...