Clinical-Based vs. Model-Based Adaptive Dosing Strategy: Retrospective Comparison in Real-World mRCC Patients Treated with Sunitinib

• 主要な著者: Florent Ferrer (著者), Jonathan Chauvin (著者), Bénédicte DeVictor (著者), Bruno Lacarelle (著者), Jean-Laurent Deville (著者), Joseph Ciccolini (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2021-05-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Different target exposures with sunitinib have been proposed in metastatic renal cell carcinoma (mRCC) patients, such as trough concentrations or AUCs. However, most of the time, rather than therapeutic drug monitoring (TDM), clinical evidence is preferred to tailor dosing, i.e., by reducing the dos...