Pharmacological p38 MAPK inhibitor SB203580 enhances AML stem cell line KG1a chemosensitivity to daunorubicin by promoting late apoptosis, cell growth arrest in S-phase, and miR-328-3p upregulation

• Main Authors: Sara Bahattab (Author), Ali Assiri (Author), Yazeid Alhaidan (Author), Thadeo Trivilegio (Author), Rehab AlRoshody (Author), Sarah Huwaizi (Author), Bader Almuzzaini (Author), Abir Alamro (Author), Manal Abudawood (Author), Zeyad Alehaideb (Author), Sabine Matou-Nasri (Author)
• Format: Book
• Published: Elsevier, 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute myeloid leukaemia (AML) is characterized by uncontrolled proliferation of myeloid progenitor cells and impaired maturation, leading to immature cell accumulation in the bone marrow and bloodstream, resulting in hematopoietic dysfunction. Chemoresistance, hyperactivity of survival pathways, and...