Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen

• Main Authors: Anna Benedykcinska (Author), Andreia Ferreira (Author), Joanne Lau (Author), Jessica Broni (Author), Angela Richard-Loendt (Author), Nico V. Henriquez (Author), Sebastian Brandner (Author)
• Format: Book
• Published: The Company of Biologists, 2016-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Targeted cell- or region-specific gene recombination is widely used in the functional analysis of genes implicated in development and disease. In the brain, targeted gene recombination has become a mainstream approach to study neurodegeneration or tumorigenesis. The use of the Cre-loxP system to stu...