Generation of brain tumours in mice by Cre-mediated recombination of neural progenitors in situ with the tamoxifen metabolite endoxifen

• Главные авторы: Anna Benedykcinska (Автор), Andreia Ferreira (Автор), Joanne Lau (Автор), Jessica Broni (Автор), Angela Richard-Loendt (Автор), Nico V. Henriquez (Автор), Sebastian Brandner (Автор)
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• Опубликовано: The Company of Biologists, 2016-02-01T00:00:00Z.
• Предметы: article
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Targeted cell- or region-specific gene recombination is widely used in the functional analysis of genes implicated in development and disease. In the brain, targeted gene recombination has become a mainstream approach to study neurodegeneration or tumorigenesis. The use of the Cre-loxP system to stu...