Design and Synthesis of Novel Nordihydroguaiaretic Acid (NDGA) Analogues as Potential FGFR1 Kinase Inhibitors With Anti-Gastric Activity and Chemosensitizing Effect

• Main Authors: Qian Chen (Author), Min Zhu (Author), Jingwen Xie (Author), Zhaojun Dong (Author), Fatehi Khushafah (Author), Di Yun (Author), Weitao Fu (Author), Ledan Wang (Author), Tao Wei (Author), Zhiguo Liu (Author), Peihong Qiu (Author), Jianzhang Wu (Author), Wulan Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant fibroblast growth factor receptor-1 (FGFR1), a key driver promoting gastric cancer (GC) progression and chemo-resistance, has been increasingly recognized as a potential therapeutic target in GC. Hereon, we designed and synthesized a series of asymmetric analogues using Af23 and NDGA as lea...