Cytokine Detection and Modulation in Acute Graft vs. Host Disease in Mice

• Main Authors: A. C. Knulst (Author), G. J. M. Tibbe (Author), C. Bril-Bazuin (Author), E. G. Breedland (Author), A. van Oudenaren (Author), R. Benner (Author), H. F. J. Savelkoul (Author)
• Format: Book
• Published: Hindawi Limited, 1994-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

A murine model for acute lethal graft vs. host disease (GVHD) was used to study the role that a number of cytokines play in the development of lethal GVHD. In this study we focused on the role of IL-1, IL-2, IL-4, IL-6, IFN-γ and TNF-α. Lethally irradiated (C57BL × CBA)F1 mice were reconstituted eit...