Nanolipid-Trehalose Conjugates and Nano-Assemblies as Putative Autophagy Inducers

• Asıl Yazarlar: Eleonora Colombo (Yazar), Michele Biocotino (Yazar), Giulia Frapporti (Yazar), Pietro Randazzo (Yazar), Michael S. Christodoulou (Yazar), Giovanni Piccoli (Yazar), Laura Polito (Yazar), Pierfausto Seneci (Yazar), Daniele Passarella (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2019-08-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

The disaccharide trehalose is an autophagy inducer, but its pharmacological application is severely limited by its poor pharmacokinetics properties. Thus, trehalose was coupled via suitable spacers with squalene (in 1:2 and 1:1 stoichiometry) and with betulinic acid (1:2 stoichiometry), in order to...