Mechanism of action of Coptidis Rhizome in treating periodontitis based on network pharmacology and in vitro validation

• Main Authors: Wei Li (Author), Ruofeng Jiao (Author), Shiyi Luo (Author), Zefei Liu (Author), Jukun Song (Author), Zhu Chen (Author)
• Format: Bog
• Udgivet: BMC, 2024-05-01T00:00:00Z.
• Fag: article
• Online adgang: Connect to this object online.

Abstract Objective Explore the therapeutic mechanism of Coptidis Rhizome (CR) in periodontitis using network pharmacology, and validate it through molecular docking and in vitro experiments. Methods Screened potential active components and target genes of CR from TCMSP and Swiss databases. Identifie...