Pro-opiomelanocortin (POMC) neuron translatome signatures underlying obesogenic gestational malprogramming in mice

• Main Authors: Roberta Haddad-Tóvolli (Author), Jordi Altirriba (Author), Arnaud Obri (Author), Elena Eyre Sánchez (Author), Iñigo Chivite (Author), Maria Milà-Guasch (Author), Sara Ramírez (Author), Alicia G. Gómez-Valadés (Author), Macarena Pozo (Author), Jasmine Burguet (Author), Licio A. Velloso (Author), Marc Claret (Author)
• Format: Book
• Published: Elsevier, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Maternal unbalanced nutritional habits during embryonic development and perinatal stages perturb hypothalamic neuronal programming of the offspring, thus increasing obesity-associated diabetes risk. However, the underlying molecular mechanisms remain largely unknown. In this study we soug...