Protective effects of paeonol on cardiovascular complications in diabetes mellitus involves modulation of PI3K /Akt-GSK-3β signalling, regulation of protease-activated receptor-1 expressions and down-regulation of inflammatory mediators

• Main Authors: Jun Li (Author), Ze-Qing Xu (Author), Ling Bao (Author), Zhi-Cao Li (Author), Jia-Xiang Qu (Author)
• Format: Knjiga
• Izdano: Bangladesh Pharmacological Society, 2015-11-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

The present study was taken as an effort to assess the effects of paeonol on diabetic cardiomyopathy. Diabetes was induced in separate groups of Sprague-Dawley rats using streptozotocin. Treatment group animals received paeonol (50, 100 or 200 mg/kg body weight/day; orally) 5 weeks after streptozoto...