Insulin-inducible THRSP maintains mitochondrial function and regulates sphingolipid metabolism in human adipocytes

• Main Authors: Maria A. Ahonen (Author), Marcus Höring (Author), Van Dien Nguyen (Author), Sami Qadri (Author), Juuso H. Taskinen (Author), Meghana Nagaraj (Author), Martin Wabitsch (Author), Pamela Fischer-Posovszky (Author), You Zhou (Author), Gerhard Liebisch (Author), P. A. Nidhina Haridas (Author), Hannele Yki-Järvinen (Author), Vesa M. Olkkonen (Author)
• Format: Book
• Published: BMC, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Thyroid hormone responsive protein (THRSP) is a lipogenic nuclear protein that is highly expressed in murine adipose tissue, but its role in humans remains unknown. Methods We characterized the insulin regulation of THRSP in vivo in human adipose tissue biopsies and in vitro in S...