Intrinsic and Extrinsic Pharmacokinetic Variability of Small Molecule Targeted Cancer Therapy

• Main Authors: Eric Reyner (Author), Bert Lum (Author), Jing Jing (Author), Matts Kagedal (Author), Joseph A. Ware (Author), Leslie J. Dickmann (Author)
• Format: Book
• Published: Wiley, 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pharmacokinetic (PK) variability in cancer clinical trials may be due to heterogeneous populations and identifying sources of variability is important. Use of healthy subjects in clinical pharmacology studies together with detailed knowledge of the characteristics of patients with cancer can allow f...