Metabolic profiling shows pre‐existing mitochondrial dysfunction contributes to muscle loss in a model of ICU‐acquired weakness

• Main Authors: Paul R. Kemp (Author), Richard Paul (Author), Aaron C. Hinken (Author), David Neil (Author), Alan Russell (Author), Mark J. Griffiths (Author)
• Format: Book
• Published: Wiley, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Surgery can lead to significant muscle loss, which increases recovery time and associates with increased mortality. Muscle loss is not uniform, with some patients losing significant muscle mass and others losing relatively little, and is likely to be accompanied by marked changes...