Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease.

• Main Authors: Paul J Converse (Author), Sandeep Tyagi (Author), Yalan Xing (Author), Si-Yang Li (Author), Yoshito Kishi (Author), John Adamson (Author), Eric L Nuermberger (Author), Jacques H Grosset (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Treatment of Buruli ulcer, or Mycobacterium ulcerans disease, has shifted from surgical excision and skin grafting to antibiotic therapy usually with 8 weeks of daily rifampin (RIF) and streptomycin (STR). Although the results have been highly favorable, administration of STR requires intramuscular...