AT7867 Inhibits the Growth of Colorectal Cancer Stem-Like Cells and Stemness by Regulating the Stem Cell Maintenance Factor Ascl2 and Akt Signaling

• Main Authors: Yuchen Li (Author), Yun Yuan (Author), Luyao Yang (Author), Hongqing Chen (Author), Xufan Zhang (Author), Tian Wen (Author), Wenhao Liao (Author), Maoyuan Zhao (Author), Ziyi Zhao (Author), Qiongying Hu (Author)
• Format: Book
• Published: Hindawi Limited, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cancer stem cells (CSCs) are the core factors leading to recurrence, insensitivity to radiotherapy and chemotherapy, and immunotherapy resistance in patients with colorectal cancer. AT7867, a potent oral AKT inhibitor, was found to have antitumor activity in colorectal cancer; however, the effect on...