In silico methods for immunogenicity risk assessment and human homology screening for therapeutic antibodies

• Main Authors: Aimee E. Mattei (Author), Andres H. Gutierrez (Author), Soorya Seshadri (Author), Jacob Tivin (Author), Matt Ardito (Author), Amy S. Rosenberg (Author), William D. Martin (Author), Anne S. De Groot (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

ABSTRACTIn silico immunogenicity risk assessment has been an important step in the development path for many biologic therapeutics, including monoclonal antibodies. Even if the source of a given biologic is 'fully human', T cell epitopes that are contained in the sequences of the biologic...