Pathogenic variants carrier screening in New Brunswick: Acadians reveal high carrier frequency for multiple genetic disorders

• Автори: Philippe Pierre Robichaud (Автор), Eric P. Allain (Автор), Sarah Belbraouet (Автор), Claude Bhérer (Автор), Jean Mamelona (Автор), Jason Harquail (Автор), Stéphanie Crapoulet (Автор), Nicolas Crapoulet (Автор), Mathieu Bélanger (Автор), Mouna Ben Amor (Автор)
• Формат: Книга
• Опубліковано: BMC, 2022-04-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Abstract Background Founder populations that have recently undergone important genetic bottlenecks such as French-Canadians and Ashkenazi Jews can harbor some pathogenic variants at a higher carrier rate than the general population, putting them at a higher risk for certain genetic diseases. In thes...