An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs

• Главные авторы: Chunwei Cao (Автор), Ying Zhang (Автор), Qitao Jia (Автор), Xiao Wang (Автор), Qiantao Zheng (Автор), Hongyong Zhang (Автор), Ruigao Song (Автор), Yongshun Li (Автор), Ailing Luo (Автор), Qianlong Hong (Автор), Guosong Qin (Автор), Jing Yao (Автор), Nan Zhang (Автор), Yanfang Wang (Автор), Hongmei Wang (Автор), Qi Zhou (Автор), Jianguo Zhao (Автор)
• Формат: ‌
• Опубликовано: The Company of Biologists, 2019-01-01T00:00:00Z.
• Предметы: article
• Online-ссылка: Connect to this object online.

Pigs share many similarities with humans in terms of anatomy, physiology and genetics, and have long been recognized as important experimental animals in biomedical research. Using an N-ethyl-N-nitrosourea (ENU) mutagenesis screen, we previously identified a large number of pig mutants, which could...