Development of a Safeguard System Using an Episomal Mammalian Artificial Chromosome for Gene and Cell Therapy

• Main Authors: Narumi Uno (Author), Katsuhiro Uno (Author), Shinya Komoto (Author), Teruhiko Suzuki (Author), Masaharu Hiratsuka (Author), Mitsuhiko Osaki (Author), Yasuhiro Kazuki (Author), Mitsuo Oshimura (Author)
• Format: Book
• Published: Elsevier, 2015-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The development of a safeguard system to remove tumorigenic cells would allow safer clinical applications of stem cells for the treatment of patients with an intractable disease including genetic disorders. Such safeguard systems should not disrupt the host genome and should have long-term stability...