3,5-Bis(arylidene)-4-piperidones as potential dengue protease inhibitors

• Ngā kaituhi matua: Hasnah Osman (Author), Nor Hashima Idris (Author), Ezatul Ezleen Kamarulzaman (Author), Habibah A. Wahab (Author), Mohd. Zaheen Hassan (Author)
• Hōputu: Pukapuka
• I whakaputaina: Elsevier, 2017-07-01T00:00:00Z.
• Ngā marau: article
• Urunga tuihono: Connect to this object online.

Dengue is a severe mosquito-borne viral infection causing half a million deaths annually. Dengue virus NS2B/NS3 protease is a validated target for anti-dengue drug design. A series of hitherto unreported 3,5-bis(arylidene)-4-piperidones analogues 4a4j were synthesized and screened in silico against...