Modeling of Oxidized PTH (oxPTH) and Non-oxidized PTH (n-oxPTH) Receptor Binding and Relationship of Oxidized to Non-Oxidized PTH in Children with Chronic Renal Failure, Adult Patients on Hemodialysis and Kidney Transplant Recipients

• Main Authors: Berthold Hocher (Author), Dominik Oberthür (Author), Torsten Slowinski (Author), Uwe Querfeld (Author), Franz Schaefer (Author), Anke Doyon (Author), Martin Tepel (Author), Heinz J. Roth (Author), Hans J. Grön (Author), Christoph Reichetzeder (Author), Christian Betzel (Author), Franz P. Armbruster (Author)
• Format: Book
• Published: Karger Publishers, 2013-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: The biological properties of oxidized and non-oxidized PTH are substantially different. Oxidized PTH (oxPTH) loses its PTH receptor-stimulating properties, whereas non-oxidized PTH (n-oxPTH) is a full agonist of the receptor. This was described in more than 20 well published studies in t...