A Marine Analgesic Peptide, Contulakin-G, and Neurotensin are Distinct Agonists for Neurotensin Receptors: Uncovering Structural Determinants of Desensitization Properties

• Main Authors: Hee-Kyoung eLee (Author), Liuyin eZhang (Author), Misty D Smith (Author), Aleksandra eWalewska (Author), Nadeem eVellore (Author), Riccardo eBaron (Author), J Michael eMcIntosh (Author), H Steve eWhite (Author), Baldomero M Olivera (Author), Grzegorz eBulaj (Author)
• Format: Book
• Published: Frontiers Media S.A., 2015-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neurotensin receptors have been studied as molecular targets for the treatment of pain, schizophrenia, addiction, or cancer. Neurotensin (NT) and Contulakin-G, a glycopeptide isolated from a predatory cone snail Conus geographus, share a sequence similarity at the C-terminus, which is critical for a...