A Drosophila model of insulin resistance associated with the human TRIB3 Q/R polymorphism

• Main Authors: Zachary Fischer (Author), Rahul Das (Author), Anna Shipman (Author), Jin-Yuan Fan (Author), Laramie Pence (Author), Samuel Bouyain (Author), Leonard L. Dobens (Author)
• Format: Book
• Published: The Company of Biologists, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Members of the Tribbles family of proteins are conserved pseudokinases with diverse roles in cell growth and proliferation. Both Drosophila Tribbles (Trbl) and vertebrate Trib3 proteins bind to the kinase Akt (Akt1) to block its phosphorylation activation and reduce downstream insulin-stimulated ana...