Advancing drug discovery through assay development: a survey of tool compounds within the human solute carrier superfamily

• Main Authors: Daniela Digles (Author), Alvaro Ingles-Prieto (Author), Vojtech Dvorak (Author), Tamara A. M. Mocking (Author), Ulrich Goldmann (Author), Andrea Garofoli (Author), Evert J. Homan (Author), Alberto Di Silvio (Author), Lucia Azzollini (Author), Francesca Sassone (Author), Mario Fogazza (Author), Felix Bärenz (Author), Antje Pommereau (Author), Yasmin Zuschlag (Author), Jasper F. Ooms (Author), Jeppe Tranberg-Jensen (Author), Jesper S. Hansen (Author), Josefina Stanka (Author), Hubert J. Sijben (Author), Helena Batoulis (Author), Eckhard Bender (Author), Riccardo Martini (Author), Adriaan P. IJzerman (Author), David B. Sauer (Author), Laura H. Heitman (Author), Vania Manolova (Author), Juergen Reinhardt (Author), Alexander Ehrmann (Author), Philipp Leippe (Author), Gerhard F. Ecker (Author), Kilian V. M. Huber (Author), Thomas Licher (Author), Lia Scarabottolo (Author), Tabea Wiedmer (Author), Giulio Superti-Furga (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2024-07-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

With over 450 genes, solute carriers (SLCs) constitute the largest transporter superfamily responsible for the uptake and efflux of nutrients, metabolites, and xenobiotics in human cells. SLCs are associated with a wide variety of human diseases, including cancer, diabetes, and metabolic and neurolo...