Regulation of PD-L1: Emerging Routes for Targeting Tumor Immune Evasion

• Main Authors: Yiting Wang (Author), Huanbin Wang (Author), Han Yao (Author), Chushu Li (Author), Jing-Yuan Fang (Author), Jie Xu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune checkpoint blockade therapies (ICBTs) targeting programmed cell death 1 (PD-1) and its ligand programmed death ligand-1 (PD-L1/B7-H1/CD274) have exhibited momentous clinical benefits and durable responses in multiple tumor types. However, primary resistance is found in considerable number of...