Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection.

• Principais autores: Brandon Trent (Autor), Yuejin Liang (Autor), Yan Xing (Autor), Marisol Esqueda (Autor), Yang Wei (Autor), Nam-Hyuk Cho (Autor), Hong-Il Kim (Autor), Yeon-Sook Kim (Autor), Thomas R Shelite (Autor), Jiyang Cai (Autor), Jiaren Sun (Autor), Donald H Bouyer (Autor), Jinjun Liu (Autor), Lynn Soong (Autor)
• Formato: Livro
• Publicado em: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Orientia tsutsugamushi infection can cause acute lung injury and high mortality in humans; however, the underlying mechanisms are unclear. Here, we tested a hypothesis that dysregulated pulmonary inflammation and Tie2-mediated endothelial malfunction contribute to lung damage. Using a murine model o...