Polarized lung inflammation and Tie2/angiopoietin-mediated endothelial dysfunction during severe Orientia tsutsugamushi infection.

• Main Authors: Brandon Trent (Author), Yuejin Liang (Author), Yan Xing (Author), Marisol Esqueda (Author), Yang Wei (Author), Nam-Hyuk Cho (Author), Hong-Il Kim (Author), Yeon-Sook Kim (Author), Thomas R Shelite (Author), Jiyang Cai (Author), Jiaren Sun (Author), Donald H Bouyer (Author), Jinjun Liu (Author), Lynn Soong (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Orientia tsutsugamushi infection can cause acute lung injury and high mortality in humans; however, the underlying mechanisms are unclear. Here, we tested a hypothesis that dysregulated pulmonary inflammation and Tie2-mediated endothelial malfunction contribute to lung damage. Using a murine model o...