Insights in the maturational processes influencing hydrocortisone pharmacokinetics in congenital adrenal hyperplasia patients using a middle-out approach

• Main Authors: Robin Michelet (Author), Davide Bindellini (Author), Johanna Melin (Author), Uta Neumann (Author), Oliver Blankenstein (Author), Wilhelm Huisinga (Author), Trevor N. Johnson (Author), Martin J. Whitaker (Author), Richard Ross (Author), Charlotte Kloft (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Introduction: Hydrocortisone is the standard of care in cortisol replacement therapy for congenital adrenal hyperplasia patients. Challenges in mimicking cortisol circadian rhythm and dosing individualization can be overcome by the support of mathematical modelling. Previously, a non-linear mixed-ef...