The role of CaMKII regulation of phospholamban activity in heart disease
Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser16 by PKA or Thr17 by Ca2+-calmodulin-dependent p...
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Format: | Book |
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Frontiers Media S.A.,
2014-01-01T00:00:00Z.
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A1234.567 |
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