The role of CaMKII regulation of phospholamban activity in heart disease

Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser16 by PKA or Thr17 by Ca2+-calmodulin-dependent p...

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Main Authors: Alicia eMattiazzi (Author), Evangelia eKranias (Author)
Format: Book
Published: Frontiers Media S.A., 2014-01-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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