The role of CaMKII regulation of phospholamban activity in heart disease

• Main Authors: Alicia eMattiazzi (Author), Evangelia eKranias (Author)
• פורמט: ספר
• יצא לאור: Frontiers Media S.A., 2014-01-01T00:00:00Z.
• נושאים: article
• גישה מקוונת: Connect to this object online.

Phospholamban (PLN) is a phosphoprotein in cardiac sarcoplasmic reticulum (SR) that is a reversible regulator of the Ca2+-ATPase (SERCA2a) activity and cardiac contractility. Dephosphorylated PLN inhibits SERCA2a and PLN phosphorylation, at either Ser16 by PKA or Thr17 by Ca2+-calmodulin-dependent p...