Skeletal myotubes expressing ALS mutant SOD1 induce pathogenic changes, impair mitochondrial axonal transport, and trigger motoneuron death

Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the loss of motoneurons (MNs), and despite progress, there is no effective treatment. A large body of evidence shows that astrocytes expressing ALS-linked mutant proteins cause non-cell autonomous toxi...

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Main Authors: Pablo Martínez (Author), Mónica Silva (Author), Sebastián Abarzúa (Author), María Florencia Tevy (Author), Enrique Jaimovich (Author), Martha Constantine-Paton (Author), Fernando J. Bustos (Author), Brigitte van Zundert (Author)
Format: Book
Published: BMC, 2024-10-01T00:00:00Z.
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3rd Floor Main Library

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