Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization

• Main Authors: Carmelo Puglia (Author), Debora Santonocito (Author), Angela Bonaccorso (Author), Teresa Musumeci (Author), Barbara Ruozi (Author), Rosario Pignatello (Author), Claudia Carbone (Author), Carmela Parenti (Author), Santina Chiechio (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity. High doses or prolonged exposure to CPS induces TRPV1 defunctionalization and, although this effect is currently used for the treatment of thermal hyperal...