Glibenclamide for the Treatment of Acute CNS Injury

• Main Authors: J. Marc Simard (Author), Nicholas M. Caffes (Author), Volodymyr Gerzanich (Author), Jason K. Karimy (Author), Adam Pampori (Author), Cigdem Tosun (Author), David B. Kurland (Author)
• Format: Book
• Published: MDPI AG, 2013-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

First introduced into clinical practice in 1969, glibenclamide (US adopted name, glyburide) is known best for its use in the treatment of diabetes mellitus type 2, where it is used to promote the release of insulin by blocking pancreatic KATP [sulfonylurea receptor 1 (Sur1)-Kir6.2] channels. During...