Acute Low Dose of Trazodone Recovers Glutamate Release Efficiency and mGlu2/3 Autoreceptor Impairments in the Spinal Cord of Rats Suffering From Chronic Sciatic Ligation

• Egile Nagusiak: Francesca Cisani (Egilea), Alessandra Roggeri (Egilea), Guendalina Olivero (Egilea), Beatrice Garrone (Egilea), Serena Tongiani (Egilea), Francesco Paolo Di Giorgio (Egilea), Anna Pittaluga (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2020-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

We investigated whether chronic sciatic ligation modifies the glutamate release in spinal cord nerve endings (synaptosomes) as well as the expression and the function of presynaptic release-regulating mGlu2/3 autoreceptors and 5-HT2A heteroreceptors in these particles. Synaptosomes were from the spi...