Convergent Synthesis of Two Fluorescent Ebselen-Coumarin Heterodimers

• Main Authors: Jim Küppers (Author), Anna Christina Schulz-Fincke (Author), Jerzy Palus (Author), Mirosław Giurg (Author), Jacek Skarżewski (Author), Michael Gütschow (Author)
• Format: Book
• Published: MDPI AG, 2016-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The organo-seleniumdrug ebselen exhibits a wide range of pharmacological effects that are predominantly due to its interference with redox systems catalyzed by seleno enzymes, e.g., glutathione peroxidase and thioredoxin reductase. Moreover, ebselen can covalently interact with thiol groups of sever...