Discovery of the First in Class 9-N-Berberine Derivative as Hypoglycemic Agent with Extra-Strong Action

• Main Authors: Mikhail V. Khvostov (Author), Elizaveta D. Gladkova (Author), Sergey A. Borisov (Author), Nataliya A. Zhukova (Author), Mariya K. Marenina (Author), Yuliya V. Meshkova (Author), Olga A. Luzina (Author), Tatijana G. Tolstikova (Author), Nariman F. Salakhutdinov (Author)
• Format: Book
• Published: MDPI AG, 2021-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Berberine is well known for its ability to reduce the blood glucose level, but its high effective dose and poor bioavailability limits its use. In this work we synthesized a new derivative of berberine, 9-(hexylamino)-2,3-methylenedioxy-10-methoxyprotoberberine chloride (<b>SHE-196</b>),...