Identification of novel pyrrolopyrimidine and pyrrolopyridine derivatives as potent ENPP1 inhibitors

• Main Authors: Hee Jin Jeong (Author), Hye Lim Lee (Author), Sung Joon Kim (Author), Jeong Hyun Jeong (Author), Su Hyun Ji (Author), Han Byeol Kim (Author), Miso Kang (Author), Hwan Won Chung (Author), Chan Sun Park (Author), Hyunah Choo (Author), Hyo Jae Yoon (Author), Nam-Jung Kim (Author), Duck-Hyung Lee (Author), Sanghee Lee (Author), Seo-Jung Han (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In an effort to discover novel scaffolds of non-nucleotide-derived Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) inhibitors to stimulate the Stimulator of Interferon Genes (STING) pathway, we designed and synthesised pyrrolopyrimidine and pyrrolopyridine derivatives and performed struct...