Sulfotransferase and Heparanase: Remodeling Engines in Promoting Virus Infection and Disease Development

• Main Authors: Dominik D. Kaltenbach (Author), Dinesh Jaishankar (Author), Meng Hao (Author), Jacob C. Beer (Author), Michael V. Volin (Author), Umesh R. Desai (Author), Vaibhav Tiwari (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

An extraordinary binding site generated in heparan sulfate (HS) structures, during its biosynthesis, provides a unique opportunity to interact with multiple protein ligands including viral proteins, and therefore adds tremendous value to this master molecule. An example of such a moiety is the sulfa...