Caffeine regulates both osteoclast and osteoblast differentiation via the AKT, NF-κB, and MAPK pathways

• Main Authors: Yue Miao (Author), Lei Zhao (Author), Shuwen Lei (Author), Chunyan Zhao (Author), Qiuping Wang (Author), Chao Tan (Author), Chunxiu Peng (Author), Jiashun Gong (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Although caffeine generally offers benefits to human health, its impact on bone metabolism remains unclear.Aim and Methods: This study aimed to systematically evaluate the long-term effects of caffeine administration on osteoclasts, osteoblasts, and ovariectomy-induced postmenopausal ost...