Penetration Efficiency of Antitumor Agents in Ovarian Cancer Spheroids: The Case of Recombinant Targeted Toxin DARPin-LoPE and the Chemotherapy Drug, Doxorubicin

• Main Authors: Evgeniya Sokolova (Author), Olga Kutova (Author), Alena Grishina (Author), Anton Pospelov (Author), Evgeniy Guryev (Author), Alexey Schulga (Author), Sergey Deyev (Author), Irina Balalaeva (Author)
• Format: Book
• Published: MDPI AG, 2019-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The efficiency of delivering a therapeutic agent into a tumor is among the crucial factors determining the prospects for its clinical use. This problem is particularly acute in the case of targeted antitumor agents since many of them are high-molecular-weight compounds. In this work, the penetration...