Lico A Causes ER Stress and Apoptosis via Up-Regulating miR-144-3p in Human Lung Cancer Cell Line H292

• Main Authors: Gang Chen (Author), Yueping Ma (Author), Zhe Jiang (Author), Yuan Feng (Author), Yueqing Han (Author), Yetian Tang (Author), Juan Zhang (Author), Hui Ni (Author), Xuezheng Li (Author), Ning Li (Author)
• Format: Book
• Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

During our study on the bioactivities of natural flavonoids, we found that the total flavonoids (TFs) and the main constituent of it, licochalcone A (lico A), activated unfolded protein response (UPR) and induced autophagy and thereby apoptosis in H292 cells. MicroRNAs, such as the tumor repressor m...