Ultrasound‐mediated delivery of flexibility‐tunable polymer drug conjugates for treating glioblastoma

• Main Authors: Tao Sun (Author), Vinu Krishnan (Author), Daniel C. Pan (Author), Sergey K. Filippov (Author), Sagi Ravid (Author), Apoorva Sarode (Author), Jayoung Kim (Author), Yongzhi Zhang (Author), Chanikarn Power (Author), Sezin Aday (Author), Junling Guo (Author), Jeffrey M. Karp (Author), Nathan J. McDannold (Author), Samir S. Mitragotri (Author)
• Format: Book
• Published: Wiley, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Effective chemotherapy delivery for glioblastoma multiforme (GBM) is limited by drug transport across the blood-brain barrier and poor efficacy of single agents. Polymer-drug conjugates can be used to deliver drug combinations with a ratiometric dosing. However, the behaviors and effectiven...