Pyrrolizine/indolizine-cinnamaldehyde Schiff bases: Design, synthesis, biological evaluation, ADME, and molecular docking study

• Auteurs principaux: Mohammed A.S. Abourehab (Auteur), Alaa M. Alqahtani (Auteur), Faisal A. Almalki (Auteur), Ashraf N. Abdalla (Auteur), Ahmed M. Gouda (Auteur)
• Format: Livre
• Publié: Elsevier, 2022-04-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

In the present study, two new Schiff bases 10a,b were synthesized by the condensation of 9a,b with cinnamaldehyde. The chemical structures of 10a,b were confirmed using spectral (IR, mass, 1H NMR, 13C NMR, and DEPT C135) and elemental analysis. The effect of 10a,b on the viability of five (SKOV-3, H...