Saturation mutagenesis defines novel mouse models of severe spine deformity

• Main Authors: Jonathan J. Rios (Author), Kristin Denton (Author), Hao Yu (Author), Kandamurugu Manickam (Author), Shannon Garner (Author), Jamie Russell (Author), Sara Ludwig (Author), Jill A. Rosenfeld (Author), Pengfei Liu (Author), Jake Munch (Author), Daniel J. Sucato (Author), Bruce Beutler (Author), Carol A. Wise (Author)
• Format: Book
• Published: The Company of Biologists, 2021-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Embryonic formation and patterning of the vertebrate spinal column requires coordination of many molecular cues. After birth, the integrity of the spine is impacted by developmental abnormalities of the skeletal, muscular and nervous systems, which may result in deformities, such as kyphosis and sco...