Isotoosendanin exerts inhibition on triple-negative breast cancer through abrogating TGF-β-induced epithelial-mesenchymal transition via directly targeting TGFβR1

• Main Authors: Jingnan Zhang (Author), Ze Zhang (Author), Zhenlin Huang (Author), Manlin Li (Author), Fan Yang (Author), Zeqi Wu (Author), Qian Guo (Author), Xiyu Mei (Author), Bin Lu (Author), Changhong Wang (Author), Zhengtao Wang (Author), Lili Ji (Author)
• Format: Book
• Published: Elsevier, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

As the most aggressive breast cancer, triple-negative breast cancer (TNBC) is still incurable and very prone to metastasis. The transform growth factor β (TGF-β)-induced epithelial-mesenchymal transition (EMT) is crucially involved in the growth and metastasis of TNBC. This study reported that a nat...