In vitro evaluation of dihydropyridine-3-carbonitriles as potential cytotoxic agents through PIM-1 protein kinase inhibition

• Asıl Yazarlar: Khalil Abnous (Yazar), Hesam Manavi (Yazar), Soghra Mehri (Yazar), Mona Alibolandi (Yazar), Hossein Kamali (Yazar), Morteza Ghandadi (Yazar), Farzin Hadizadeh (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Wolters Kluwer Medknow Publications, 2017-01-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

PIM-1 protein kinase inhibitor belongs to a novel class of serine/threonine kinases. As PIM-1 is overexpressed in cancer cells and possesses oncogenic functions, its inhibition provides a new option in cancer therapy. In this study, in vitro inhibitory effects of seven analogues of 1, 2-dihydropyrid...