N,N-Dimethyl-3β-hydroxycholenamide Reduces Retinal Cholesterol via Partial Inhibition of Retinal Cholesterol Biosynthesis Rather Than its Liver X Receptor Transcriptional Activity

N,N-dimethyl-3β-hydroxycholenamide (DMHCA) is an experimental pharmaceutical and a steroidal liver X receptor (LXR) agonist, which does not induce undesired hepatic lipogenesis. Herein, DMHCA was evaluated for its retinal effects on normal C57BL/6J and Cyp27a1−/−Cyp46a1−/− mice; the latter having hi...

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Main Authors: Nicole El-Darzi (Author), Artem Astafev (Author), Natalia Mast (Author), Aicha Saadane (Author), Morrie Lam (Author), Irina A. Pikuleva (Author)
Format: Book
Published: Frontiers Media S.A., 2018-07-01T00:00:00Z.
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3rd Floor Main Library

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Call Number: A1234.567
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